(1) Prevention

Because of the carcinogenic potential of HSV, live attenuated vaccines and dead vaccines should not be used in humans. Various vaccines under study, such as envelope protein (purified gG, gD) subunit vaccines, gB, gD gene recombinant vaccinia virus vaccines and peptide vaccines, have shown good results in animal experiments and have application prospects.

Pregnant women's birth canal HSV-2 infection, after delivery can give neonates gamma globulin for emergency prevention.

(2) Treatment

Herpes net (IDU), cytarabine (Ara-C), arabinosine adenosine (Ara-A), bromoethylene uridine (BVDU) and other effective medical education for the treatment of herpes keratitis | Combined use can increase effectiveness. Domestic eye drops made with HSvgCgD monoclonal antibody are used to treat herpetic keratitis, and have achieved remarkable results.

Acyclovir (ACV) is a highly selective drug for herpes virus. ACV must be activated by HSV thymidine kinase (TK) and then phosphorylated to monophosphorylated ACV, and then phosphorylated by cell kinase to di-triphosphorylated ACV. ACV-ATP is highly competitive with dGTP, so it can be terminated Viral DNA synthesis. ACV is mainly used to treat genital herpes infections, shorten the local detoxification time, and early local healing. In addition, ACV is also commonly used to treat cold sores, herpes encephalitis, neonatal herpes, herpes keratitis, etc., all of which have curative effects.

Ara-A (Ara-A) can be phosphorylated into active Ara-ATP through the action of host kinase, selectively inhibit HSV polymerase, and terminate viral DNA synthesis. Since Ara-A does not require the action of HSvTK enzyme, it can be used for the treatment of infections resistant to ACV strains (TK-strains). It can prevent the serious deterioration of herpes keratitis lesions and reduce the mortality of herpetic encephalitis and HSV systemic infection.

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