Cellular aging
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September 21 12:07:08, 2024
Cell aging Normal cells have a limited number of divisions. Therefore, cells obtained from normal tissues will die after a certain number of divisions. This phenomenon is called cell aging. It is now believed that aging is due to the DNA ends of telomeres The sequence cannot be replicated normally during each cell division and gradually becomes shorter. As a result, the telomere continues to shorten as the number of cell divisions increases, and eventually the cell can no longer divide [Bodnet et al., 1998]. However, reproduction This is not the case with cells, stem cells, and transformed cells. These cells often extend the lifespan of cells by expressing telomerase that can replicate telomere DNA, and even make germ cells and some tumor cells have unlimited proliferation capacity.