The on-chip lab-microfluidics technology (Microfluidics) integrates the basic operations of sample preparation, reaction, separation, and detection in biological, chemical, and medical analysis processes onto a micrometer-scale chip to automate the entire process of analysis. . Due to its great potential in the fields of biology, chemistry, medicine, etc., it has developed into a new research field of biology, chemistry, medicine, fluids, electronics, materials, machinery and other disciplines.

Organs-on-a-chip is an emerging cutting-edge interdisciplinary technology developed in recent years. It has witnessed the biological behavior of the organism in an unprecedented way, in new drug discovery, disease mechanism and toxicity prediction. Other fields have important application prospects.

The Autonomous University of Madrid and ceramic 3D printing company Lithoz have jointly developed a complex 3D printed ceramic microsystem that can advance the development and application of chip labs and human chip organs. The development team said its 3D printed ceramics marks a breakthrough in biomedical science.

Using Lithoz's CeraFab 7500 machine (a lithography-based additive manufacturing system), the ceramic material is mixed with a photosensitive resin and printed in 3D. After the octagonal chip is printed, the resin is removed by sintering, and the ceramic particles are fused. Together become a solid piece. This step is important because it meets the biomedical performance requirements of the sealing material required by the chip (to prevent leakage of living materials). 　

According to researchers, this 3D printed ceramic chip shows the potential to use ceramic materials for biomedical applications because they have higher strength and better temperature resistance than glass or plastic.

The 3D printed ceramic microsystem is one-shot, meaning it does not require any components and requires no component maintenance. As part of its structure, the composite microsystem incorporates a porous membrane that separates different levels of cell culture chambers, similar to the function of transwell.

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