Shanghai Jiaotong University participates in an international alliance to study the genetic mechanism of adverse drug reactions

China Education Equipment Purchasing Network News: Recently, the International Serious Adverse Events Alliance announced that it will work with Shanghai Jiaotong University and its more than 30 hospital networks to study the genetic mechanism of serious adverse drug events in the Chinese population. The Bio-X Research Institute participating in this international cooperation project is an important research institution of Shanghai Jiaotong University. One of its main research directions is to focus on the genetic and molecular mechanisms of disease and drug response.

Allegedly, the International Serious Adverse Events Alliance will collect case studies through the network of international academic institutions and a health management system (with a strong electronic health management database). The cases are mainly immune system-mediated adverse drug reactions, such as drug-induced liver injury , Kidney injury, severe rash reaction, and acute hypersensitivity syndrome. The main purpose of this collaborative study is to further explore the ethnic differences in the genetic mechanisms of serious adverse drug events through the study of the Chinese population. Academician He Lin and Associate Professor Qin Shengying of Bio-X Research Institute of Shanghai Jiaotong University will be responsible for this cooperation project. International Serious Adverse Events Alliance will provide financial support. The first phase of the cooperation will last about two years.

According to reports, about 100,000 people die from adverse drug reactions in the United States each year, and about 190,000 people die from adverse drug reactions in China every year. Adverse drug reactions have gradually become one of the important inducements that cause doctor-patient contradictions and disputes, and also affect human health. Important factor.

The International Serious Adverse Events Alliance is a non-profit international research organization jointly organized by global pharmaceutical companies and the Wellcome Foundation to better reveal the role of genetic factors in drug safety. The alliance hopes that by conducting a better safety risk analysis before new drugs enter the market, the future drug treatment process will be more complete, safe and effective. The alliance allows qualified researchers to obtain relevant research data and results for free.

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